Acceleration of bone-marrow recovery by pre-treatment with cyclophosphamide in patients receiving high-dose melphalan.
- Resource Type
- Academic Journal
- Authors
- Hedley, D W; McElwain, T J; Millar, J L; Gordon, M Y
- Source
- Lancet (LANCET), 11/4/1978; 2(8097): 966-968. (3p)
- Subject
- Language
- English
- ISSN
- 0140-6736
7 patients with advanced malignant melanoma who were given cyclophosphamide (500 mg intravenously) 7 days before a high dose of melphalan (140 mg/m2) had a more rapid recovery of the peripheral white-cell count than did 4 patients who received melphalan alone. "Priming" by cyclophosphamide might be a practicable means of offsetting the bone-marrow toxicity of some chemotherapy regimens and it may permit higher doses of drugs to be given safely.