Purpose: To evaluate three methods for treating adult laryngeal hemangiomas: conventional chemotherapy, CO2 laser combined with chemotherapy, and KTP laser. And to identify risk factors that affected the prognosis of the lesions. Method: A retrospective analysis was performed on the data from patients with adult laryngeal hemangiomas treated by one of three aforementioned methods, the curative efficacy, and safety of those methods was compared. Results: All cases were confirmed by suspension micro-laryngoscope examination. Pre- and post-treatment clinical photographs were taken and the outcomes were graded. Thirty-eight patients in 48 different cases were enrolled in the study between June 2010 and June 2016, and some patients were treated more than once. The treatment efficacy of the KTP laser was higher than that of chemotherapy according to the Kruskal-Wallis ANOVA test; however, the ordinal logistic regression showed that the choice of surgical procedure did not affect the treatment results; only the size of the bases of the lesions affected the prognosis of adult laryngeal hemangiomas. Conclusions: Pingyangmycin injection, KTP laser, and CO2 laser combined with chemotherapy are safe and effective methods for the treatment of adult laryngeal hemangiomas. The size of base of the lesion affects the prognosis of the hemangiomas.
目的:评价三种治疗成人喉血管瘤的方法:常规化疗、CO2激光-化疗联合疗法及KTP激光疗法。并找出影响该病预后的危险因素。 方法:对接受上述三种方法之一治疗的成人喉血管瘤患者的资料进行回顾性分析, 并比较不同方法的疗效和安全性。 结果:所有病例均经悬吊微镜喉镜检查证实。治疗前和治疗后进行临床照相, 对结果进行分级。 2010年6月至2016年6月期间, 48个不同病例的38位患者参加了研究, 部分患者接受了一次以上的治疗。根据Kruskal-Wallis ANOVA检验, KTP激光的治疗效果高于化疗;然而, 有序逻辑回归分析显示, 手术方式的选择并不影响治疗效果, 只有病变基底的大小才会影响成人喉血管瘤的预后。 结论:平阳霉素注射液、KTP激光、CO2激光-化疗联合疗法是治疗成人喉血管瘤的安全有效的方法。病变基底的大小影响血管瘤的预后。