Background: It is important to determine the factors affecting nursing competence, which ensures that care is carried out safely and in accordance with ethical principles. Objective: This study was carried out to examine the effect of nurses' attitudes towards evidence-based nursing on their holistic nursing competence. Methodology: The sample of this descriptive study consists of 112 nurses working across Turkey. Results: It was determined that nurses' attitudes towards evidence-based nursing changed significantly by their educational levels, their knowledge of evidence-based practices, and their status of following the scientific researches. Nurses' holistic nursing competencies were found to vary significantly by working year, educational level, level of knowledge about evidence-based practices, and status of following the scientific researches. It was found that there was a positive significant relationship between Attitude Towards Evidence-Based Nursing and Holistic Nursing Competence. Conclusions: Nurses' attitudes towards evidence-based nursing positively affect their holistic nursing competencies. This study revealed that when the nurses base their nursing practices in the clinic on evidence, this shall become effective in enhancing competence levels.