Acute facial-nerve injury. To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration. Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks. The mean eye-closure movement score in Group B was significantly higher than that in Group F (p <.001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p =.001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p <.001). Furthermore, an improvement in nerve ultrastructure was observed in Group B. PRF application has a positive effect on nerve recovery after anastomosis. Contribute to the literature to improve nerve regeneration.
背景:急性面神经损伤。 目的:探讨富血小板纤维蛋白(PRF)和地塞米松对神经再生的作用。 材料与方法:36只大鼠随机分为6组。 除 E 组外, 所有组均使用全层切口制造面神经损伤。接下来, 对A、B、C、D、F 组分别进行一期吻合术、施用PRF、局部施用地塞米松、一期吻合术带局部施用PRF 和地塞米松, 以及无面神经修复。八周后评估临床、功能和结构的改进。 结果:B组平均闭眼运动评分显著高于F组(p<.001)。 B组的平均胡须运动得分显著高于F组(p=.001)。 F组胡须运动的平均幅度明显低于A、B、C、E组, D组平均振幅明显低于E组(p<.001)。 此外, B 组的神经超微结构有所改善。 结论:PRF的施用对吻合术后神经恢复具有积极作用。 意义:为关于改善神经再生的文献资料增添了内容。