The aim of this study was to examine the intrapartum maternal risk factors as predictors of the occurrence of early neonatal infection. Patients and Methods: This retrospective study included 957 mothers with one or more risk factors for early neonatal infection (urinary infection, excessive vaginal discharge, febrile state, premature rupture of fetal membranes, chorioamnionitis) and their newborns with gestational age of 37-42 weeks, both sexes, from singleton pregnancies and without visible anomalies. Results: Out of all newborns 74% were healthy newborns, 24% with probable and 2% with proven neonatal infection. There was 87.15% of newborns with one intrapartum risk factor, 12.02% with two risk factors and only two of newborns (0.6%) whose mothers had three risk factors for development of early neonatal infection. Excessive vaginal discharge was the most common risk factor in all three groups of newborns. In the group of newborns with probable infection the most common risk factors are premature rupture of fetal membranes (41.33%) and urinary infection (30.22%), while in newborns with proven infection most common risk factors are chorioamnionitis (31.58%) and febrile states (21.05%). The strongest predictor for the occurrence of proven neonatal infection was chorioamnionitis with probability quotient 307.76. Conclusion: Chorioamnionitis has a significant validity in early diagnosis and timely treatment of early neonatal infection.