Aim: Anemia is a marker of severity in patients with diabetes mellitus, associated with higher mortality. Aim of this study was to test its impact on diabetic foot (DF) inpatients. Method: We retrospectively searched patients admitted for DF in our Department between July and December 2021 (Group A) and compared them with patients admitted in the same period in Diabetology Department for diabetes-related diagnosis different from DF (Group B). We compared demographic and clinical characteristics focusing on blood crasis: mean (HB) or maximum (HHB) haemoglobin concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin content (MCH), mean corpuscular hemoglobin content (MCHC), red blood cell count (RBC) and hematocrit (HCT) were extracted from charts at admission. Length of admission and in-hospital mortality were compared. Results / Discussion: We studied 211 patients: 106 in Group A and 105 in Group B. No differences in age while patients of Group A had a longer disease duration (19.4±11.3 yrs vs 7.96±10.4 yrs, p<0.05). Anemia was more prevalent in Group A (72.6%) than B (52.3%): p<0.01. HB (10.34±2.0 g/dl vs 11.1±2.2 g/dl, p<0.05) was significantly lower in Group A with no difference in HHB, MCV, MCH and MCHC. HCT was significantly lower in Group A (32.3±5.7% vs 36.5±7.3%, p<0.05) as well as RBC (3.7±0.7x106/microl vs 4.2±0.8 106/microl, p<0.05). Group B showed longer duration of admission (13.8±9.6 days vs 7.6±4.9 days, p<0.001) and higher mortality rate during admission (8.58% vs 0.94%, p<0.01). Conclusion: Despite its high prevalence in DF inpatients, anemia is not associated with a worse short-term prognosis.