Background; Children with acute leukemia are at high risk of hepatitis C infection, either by imunosuppression secondary to chemotherapy or by multiple transfusions of blood products during the course ofthe disease. Hepatitis C constitute a major problem during management ofacute leukemias due to resultant Portal hypertension, or bleeding esophageal varices. Chronic HCV infection is a major cause ofliver cirrhosis and hepatocellular carcinoma in leukemic survivors. Aim: In the present study we tested the effect ofAmlodipine on children ofacute lymphoblastic leukemia having portal hypertention secondary to hepatitis c infection during maintenance chemotherapy. Results: From this study, we found that Amlodipille was effective in reducing the elevated portal blood pressure to normal level in doses which does not interfer with mechanism of action ofchemotherapy. Conclusion: Treatment with Amlodipine can be used to control portal hypertension in leukemic children having hepatitis c virus induced portal hypertension.