Aim: Four-layer bandage systems (4LB) is the traditional choice for the management of lower extremity edema. Though more expensive, a novel two-layer dual compression system bandage (2LB) has found favor due to improved wound healing rate associated with compliance. The objective of this study was to estimate the time and labor costs of patients treated with a 4LB or 2LB system. Method: All clinically indicated patients presenting at a single wound care center were included over the course of a single day. Patients were randomized to 4LB or 2LB system and bandaged by an experienced clinician. The time of bandage application was calculated by an independent observer and divided by the total number of patients to determine the average. Labor costs were determined by multiplying the times by average labor and overhead costs. Results / Discussion: 40 patients were randomized to 4LB or 2LB. 46:00 minutes (2:18 minutes/limb) was spent applying the 4LB versus 31:40 minutes (1:35 minutes/limb) applying the 2LB. The 2LB saved nearly 15 minutes over 20 patients. The labor and overhead costs associated with applying the 4LB and 2LB were $19.93 and $13.72 for the day, a labor saving of $ 6.51. Conclusion: Over 30-day period, 942 limbs were bandaged in this center. Use of 2LB system would result in 11.25 hours saved and $292.54 saved in labor. The 11.25 hours saved can be better used for seeing 65 additional patients, which is more beneficial to the community, and this also can generate an estimated $ 15210 at average patient revenue rates. Also significant are obvious environmental benefits in using a 2LB which generates less medical waste.