Aim: The use of compression in the management of the venous reflux condition is highly recommended but the use of bandages on venous ulcer patients with diabetes is less researched. General concern exists about affecting circulation in diabetic patients via improperly applied compression. The Dual Compression System (DCS) is designed to confidently apply consistent therapeutic pressure (30-50 mm Hg) via visual indicators. A post-hoc analysis of a real-life study on patients with both the venous and diabetic condition is presented. Method: The clinical data from a large prospective, multicentre, observational study, including diabetic and non-diabetic patients treated with DCS in outpatient/home visits for a maximum duration of six weeks (4 clinician visits maximum) were analysed. Main measures included wound healing/reduction, oedema/ankle mobility, tolerability /acceptance. Circulation was checked in diabetic patients before compression, standard clinical procedure. Results / Discussion: Of 677 venous ulcer patients studied, 185 (27.3%) were diabetic. At final visit (mean 28d), wound closure (33.9% diabetic vs 30.2% nondiabetic), and oedema resolution (67.3% vs 66.2% p=0.805) were similar between diabetic/ nondiabetic. Slippage was same (<4%) in both, most reported no discomfort. At the first interim visit, tightness sensation, warm feeling or pain were more for diabetics. These differences ended at final visit, except pain 11.9% (diabetic) vs 6.1% (non-diabetic). Patient tolerance was comparable, and high, in both groups. Conclusion: DCS demonstrated similar efficacy and high safety profile in both diabetic/non-diabetic patients. This real-life evidence is consistent with clinical evidence on DCS from RCTs, clinical trials, case series data. Diabetic patients do need to be checked well for circulatory status and some may face more pain than nondiabetic patients with compression.