Aim: Compression, the gold standard for venous insufficiency is underutilized on other edematous conditions, particularly diabetes/diabetic ulcer, but also trauma, surgical dehiscence, and mixed venous arterial diseases. An engineered compression therapy combining long and short stretch bandaged can treat many types of edema of variable origin including diabetes and DFUs. This study aims to demonstrate versatile use of compression in a busy wound center. Method: Over a 30 day period, every application of DCS was recorded, with primary /relevant secondary diagnosis indicating compression use. Results / Discussion: 1,090 patient visits occurred from 334 patients, 199 (60%) of who obtained compression at their first visit. 942 total compression bandages were done over 30 days (248 on 199 patients on the first day of compression). Venous Insufficiency (Ulcer + No Ulcer) 113, DFU 41, trauma 23, orthopedic dehiscence 15, diabetic amputation/dehiscence 4, and BKA 3 were the etiologies presented by the 199 that required compression upon admission. Of these, 102 (51%) had diabetes. Conclusion: The DCS product is quite versatile. It can treat several underserved edematous conditions e.g diabetes or dehiscence. Venous insufficiency dominated (56% admissions), DFU edema was the indication in 20% of admits. Dehiscence/trauma/ amputation edema were also successfully treated (smaller in proportion). For diabetes, detailed vascular consideration was made for every patient. With this protective approach, it is noteworthy that 51% of our admitted patients were successfully treated with compression with no complications seen. Informed clinical practice (vascular diagnosis without exception) and the use of an engineered compression system can treat the diabetic population which is often untreated for reasons of medical concern related circulation impairment caused by compression.