Journal of Physics. A. Mathematical and Theoretical (J. Phys. A) (20230101), 56, no.~45, Paper No 455002, 25~pp. ISSN: 1751-8113 (print).eISSN: 1751-8121.
Subject
92 Biology and other natural sciences -- 92C Physiological, cellular and medical topics 92C05 Biophysics
Summary: ``Understanding how a stressor applied on a biological system shapes its evolution is key to achieving targeted evolutionary control. Here we present a toy model of two interacting lattice proteins to quantify the response to the selective pressure defined by the binding energy. We generate sequence data of proteins and study how the sequence and structural properties of dimers are affected by the applied selective pressure, both during the evolutionary process and in the stationary regime. In particular we show that internal contacts of native structures lose strength, while inter-structure contacts are strengthened due to the folding-binding competition. We discuss how dimerization is achieved through enhanced mutability on the interacting faces, and how the designability of each native structure changes upon introduction of the stressor.''