Psychophysiological Correlates of Developmental Changes in Healthy and Autistic Boys.
- Resource Type
- Article
- Authors
- Weismüller, Benjamin; Thienel, Renate; Youlden, Anne-Marie; Fulham, Ross; Koch, Michael; Schall, Ulrich,
- Source
- Journal of Autism & Developmental Disorders; Jul2015, Vol. 45 Issue 7, p2168-2175, 8p, 2 Charts, 1 Graph
- Subject
- Sensory disorders
Adolescence
Autism
Child development
Data analysis
Analysis of variance
Electroencephalography
Evoked potentials (Electrophysiology)
Psychophysiology
Research funding
Social skills
Sound
Statistics
T-test (Statistics)
Data analysis software
Descriptive statistics
Disease complications
Diagnosis
New South Wales
- Language
- ISSN
- 01623257
This study investigated neurodevelopmental changes in sound processing by recording mismatch negativity (MMN) in response to various degrees of sound complexity in 18 mildly to moderately autistic versus 15 healthy boys aged between 6 and 15 years. Autistic boys presented with lower IQ and poor performance on a range of executive and social function measures when compared to their healthy counterparts. We found that MMN in response to duration deviants was less lateralized in the clinical group whereas larger amplitudes correlated with advanced age, thus capturing neurodevelopmental changes. Larger MMN in response to speech-like sound deviants was associated with better verbal fluency and executive function performance, respectively, but did not reliably discriminate the two groups. [ABSTRACT FROM AUTHOR]