In an introduction to the issue, the writers examine interdisciplinary and cross-institutional collaboration in higher education to bring about reform in science, mathematics, and technology education. The issue features five studies by faculty members immersed in interdisciplinary and cross-institutional collaborative endeavors. These studies examine some of the questions of education reform addressed in reports such as Before It's Too Late; Shaping the Future: New Expectations for Undergraduate Education in Science, Mathematics, Engineering, and Technology; and The Role of Scientists in the Professional Development of Science Teachers. The writers provide brief summaries of the five studies.