Design of Pyridopyrazine-1,6-dione gamma-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability
- Resource Type
- Journal
- Authors
- Pettersson, Martin; Johnson, Douglas S.; Humphrey, John M.; Butler, Todd W.; Ende, Christopher W. Am; Fish, Benjamin A.; Green, Michael E.; Kauffman, Gregory W.; Mullins, Patrick B.; O'Donnell, Christopher J.; Stepan, Antonia F.; Stiff, Cory M.; Subramanyam, Chakrapani; Tran, Tuan P.; Vetelino, Beth Cooper; Yang, Eddie; Xie, Longfei; Bales, Kelly R.; Pustilnik, Leslie R.; Steyn, Stefanus J.; Wood, Kathleen M.; Verhoest, Patrick R.
- Source
- ACS MEDICINAL CHEMISTRY LETTERS; MAY 2015, 6 5, p596-p601, 6p.
- Subject
- Language
- English
- ISSN
- 19485875