Genetic toxicology of putative nongenotoxic carcinogens
- Resource Type
- Technical Report
- Authors
- Source
- Other Information: Pub. in Mutation Research, Vol. 296, No. 3, 241-277(1993)
- Subject
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ORGANIC COMPOUNDS
TOXICITY
ANEUPLOIDY
CARCINOGENS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
GENE MUTATIONS
GLOBAL ASPECTS
HUMAN POPULATIONS
RESEARCH PROGRAMS
SAFETY STANDARDS
US EPA
USA
DEVELOPED COUNTRIES
MUTATIONS
NATIONAL ORGANIZATIONS
NORTH AMERICA
PLOIDY
POPULATIONS
STANDARDS
US ORGANIZATIONS 560300* -- Chemicals Metabolism & Toxicology
- Language
- English
The report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the US Environmental Protection Agency/International Agency for Research on Cancer genetic activity profile (EPA/IARC GAP) database, these agents are classified on the basis of their mutagenicity emphasizing three genetic endpoints: gene mutation, chromosomal aberration and aneuploidy. On the basis of results of short-term tests for these effects, criteria was defined for evidence of mutagenicity (and nonmutagenicity) these criteria were applied in classifying the group of putative nongenotoxic carcinogens. The results from this evaluation based on the EPA/IARC GAP database are presented along with a summary of the short-term test data for each chemical and the relevant carcinogenicity results from the NTP, Gene-Tox and IARC databases. The data clearly demonstrate that many of the putative nongenotoxic carcinogens that have been adequately tested in short-term bioassays induce gene or chromosomal mutations or aneuploidy.