Construction of a risk model based on N6-methyladenosine-related lncRNAs for predicting the prognosis of breast cancer
- Resource Type
- Original Paper
- Authors
- Cui, Wenxia; Zhang, Jiasheng; Lin, Junyu; Xu, Sunwang; Kong, Lingjun; Lin, Wei; Xue, Jiajie; Wang, Qingshui; Lin, Yao; Zhu, Youzhi
- Source
- Journal of Biosciences: Published by the Indian Academy of Sciences. 48(3)
- Subject
- Breast cancer
lncRNA
N6-methyladenosine
prognostic model
TCGA database
- Language
- English
- ISSN
- 0973-7138
N6-methyladenosine modification and lncRNAs are closely related to the prognosis and immunotherapy response of breast cancer patients. LncRNAs related to m6A-associated genes were predicted based on co-expression analysis of the TCGA database. We established a novel 7-m6A-associated lncRNA signature for predicting patient prognosis and validated it. The model was significantly correlated with survival time and survival status and was an independent predictor of overall survival (OS). Except for the M1 disease group, the model had good predictive value for OS in different subgroups. We constructed a prognostic model based on 7 m6A-associated lncRNAs in breast cancer. This model could serve as an independent prognostic factor with tremendous predictive ability for breast cancer patients.