For optimal antibody effectiveness, sometimes less is more
- Resource Type
- News
- Authors
- Wülfing, Christoph; Dovedi, Simon J.
- Source
- Nature: International weekly journal of science. 614(7948):416-418
- Subject
- Immunology
Medical research
- Language
- English
- ISSN
- 0028-0836
1476-4687
Antibodies that activate stimulatory or inhibitory receptors are of great therapeutic interest for the treatment of cancer or autoimmune diseases. It emerges that such antibodies work better if they don’t bind to receptors too tightly.
Modulating receptor-binding affinity influences antibody effectiveness.