In Vivo Wound-Healing Activity of Glycerohydrogel Plates Based on Ascorbate Chitosan, Aloe vera, and Silicon Polyolate
- Resource Type
- Original Paper
- Authors
- Malinkina, O. N.; Zhuravleva, Yu. Yu.; Shipovskaya, A. B.
- Source
- Applied Biochemistry and Microbiology. 58(2):161-165
- Subject
- wound-healing activity
glycerohydrogel
chitosan
L- and D-ascorbic acid
Aloe vera juice
silicon tetraglycerolate
- Language
- English
- ISSN
- 0003-6838
1608-3024
An in vivo study of the healing properties of the glycerohydrogel plates based on L- and D-ascorbate chitosan, Aloe vera juice, and silicon tetraglycerolate in the treatment of a cut wound in male albino rats was carried out. It was found that the use of the plates statistically significantly increased the rate of decrease in the area of the wound surface and the rate of wound healing and reduced the period of skin restoration as compared with the control. The highest rate of regeneration was observed under plates with chitosan D-ascorbate, which confirmed the previously discovered effect of homochirality of chitosan salts on the biological functionality of its materials. Glycerohydrogel plates based on D-ascorbate chitosan are highly effective wound dressings and are economically feasible due to the lower cost of the D isomer of ascorbic acid.