Summary: The chromatographic behavior of 12 newly synthesized thiazoles has been studied by thin-layer chromatography. The relationship between the RF values of the thiazoles and mobile-phase composition has been determined for normal-phase (NP) systems of the type silica—non-polar diluent (hexane)—polar modifier (ethyl acetate, acetone, or dioxane), for reversed-phase (RP) systems of the type paraffin oil-impregnated silica—concentrated ammonia—polar modifier (methanol, acetone, or dioxane), and for rice starch—concentrated ammonia—polar modifier (methanol, acetone, or dioxane). The retention observed for different mobile-phase modifiers and different stationary phases was compared. The correlation between the retention of the compounds investigated in normal- and reversed-phase liquid chromatography and their octanol—water partition coefficients expressed as log P (which ranged between 2.33 and 5.94), was examined.