Objectives: Whereas extant literature abounds with works on breastfeeding and its implications for child health and survival, there is very limited research on the challenges faced by disabled women in breastfeeding their infants and children. This study explored the challenges facing disabled women in the Kumasi Metropolis in exclusively breastfeeding their infants using qualitatibve research design.Methods: Using a sample of 55 from the communities and key informants the snowballing and purtposive sampling techniques were used. The thematic approach was used in the analysis which was done manually.Results: Most disabled women have Caesarean deliveries which could challenge exclusively breastfeed their infants. It was observed that disabled mothers generally have a low level of education, mostly unmarried and not gainfully employed. Secondly, most disabled mothers go through a Caesarean section during birth which makes it pretty difficult for them to exclusively breastfeed their infants. Apart from disabilities such as physical impairment, deafness and blindness which could challenge women exclusively breatfeed their children, additionally some health professionals discourage them from doing so. Some women and relatives of the disabled discourage them from exclusively breastfeeding their infants either through lack of awareness of the efficacy of the practice or the stress their involvement in exclusive breastfeeding brings upon the women themselves.Conclusions: Various forms of disability, and dsiscouragement from some health professionals and family members may constrain disabled women from exclusively breatfeeding their infants. Recommendations include, implementing the Disability Act, creating special wards for disabled women in the health institutions and orienting the medical staff on their professional responsibilities in taking care of the disabled.