MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy
- Resource Type
- Letter
- Authors
- Pulickal, Tina; Boos, Johannes; Konieczny, Markus; Sawicki, Lino Morris; Müller-Lutz, Anja; Bittersohl, Bernd; Gerß, Joachim; Eichner, Markus; Wittsack, Hans-Jörg; Antoch, Gerald; Schleich, Christoph
- Source
- European Radiology. 29(12):6443-6446
- Subject
- Language
- English
- ISSN
- 0938-7994
1432-1084
Key Points: • Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations.