Neutrophil extracellular traps and pulmonary fibrosis: an update
- Resource Type
- Review Paper
- Authors
- Yan, Suyan; Li, Meiqi; Liu, Baocheng; Ma, Zhenzhen; Yang, Qingrui
- Source
- Journal of Inflammation. 20(1)
- Subject
- Pulmonary fibrosis
Neutrophil extracellular traps
Interstitial lung disease
- Language
- English
- ISSN
- 1476-9255
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding the pathways by which NETs contribute to the disease is crucial for developing effective treatments. This review focuses on the formation of NETs and the common mechanisms of NETs in PF.
Highlights: 1. This review focuses on NETs formation and the role of NETs in PF and presents research progress.2. We describe specific mechanisms by which NETs induce PF in fibroblasts while revealing the transduction mechanisms that remain to be investigated.3. We explore the possible consequences of NETs action on lung epithelial cells, including NETs-induced lung epithelial damage and NETs-driven epithelial mesenchymal transition.4. We introduce recent key findings about the role of NETs-mediated chronic inflammation in PF and the effect of autophagy-driven production of NETs in fibrosis.