RETRACTED ARTICLE: The amine-catalysed Suzuki–Miyaura-type coupling of aryl halides and arylboronic acids
- Resource Type
- Original Paper
- Authors
- Xu, Lei; Liu, Fu-Yue; Zhang, Qi; Chang, Wei-Jun; Liu, Zhong-Lin; Lv, Ying; Yu, Hai-Zhu; Xu, Jun; Dai, Jian-Jun; Xu, Hua-Jian
- Source
- Nature Catalysis. 4(1):71-78
- Subject
- Language
- English
- ISSN
- 2520-1158
Suzuki–Miyaura coupling is a practical and attractive carbon−carbon bond formation reaction due to its high efficiency and wide functional group compatibility, but its industrial applications are limited because it is typically catalysed by expensive palladium-containing transition-metal complexes. Here we show a robust and chemoselective organocatalytic Suzuki−Miyaura-type coupling of aryl halides with arylboronic acids catalysed by amines. The utility and scope of this reaction were demonstrated by the synthesis of several commercially relevant small molecules and a selection of derivatives of pharmaceutical drugs.
The coupling of aryl halides and arylboronic acids is generally performed by metal-catalysed Suzuki–Miyaura reactions while metal-free approaches remain elusive. Here an organocatalytic approach based on amine catalysts is introduced for the preparation of commercially relevant asymmetric biaryls.