Purpose of Review: Cancer immune evasion is still a major obstacle in elimination of cancer cells and current cancer treatment. This review focuses on immune evasion mechanisms at each step of the cancer immune cycle to better understand the escape of the tumor cells from the immune system and to provide insight to guide the design of effective anticancer therapeutic strategies.Recent Findings: There are a number of factors that contribute to immune escape, including restriction of antigen recognition, inhibition of immune system cells, immunosuppressive effects, and accumulation of specific metabolites in TME. However, identification of immune escape mechanisms in cancer still remains an active area of research, as both tumor and immune response in individuals are heterogeneous and diverse.Summary: A better understanding of immune escape mechanisms in cancer can provide the development of clinically applicable therapeutic options in a range of cancers and contribute to the management of the disease.