Background: The German board of EMS medical directors, the “Bundesverband der Ärztlichen Leiter Rettungsdienst”, recommended a comprehensive catalogue of drugs that may be administered by paramedics. We evaluated how often paramedic students administered these drugs during their training.Methods: We asked 71 students how often they administered 30 different drugs during their training. Statistical analysis was performed with SOFA (Paton-Simpson and Associates Ltd, USA). The Results are displayed as mean (SD).Results: Intravenous epinephrine was administered 2.22 (6.67) times. Atropine was used for treatment of bradycardia 1.18 (1.97) times. Benzodiazepines were administered 7.27 (10.28) times prehospital. Inhaled beta-agonists were given 8.89 (8.06) times, ipratropium bromide 3.70 (5.91) times, steroids 3.79 (5.32) times and antihistamines 1.82 (4.34) times prehospital. Ondansetron was given 14.38 (35.06) times in-hospital. Dimenhydrinate was the most widely used antiemetic in the prehospital environment with 8.14 (10.14) administrations. Furosemide was used 6.06 (9.45) times prehospital. Heparin was used 12.00 (14.32) times, acetylsalicylic acid 14.32 (14.29) times and glyceroltrinitrate 12.25 (10.87) times prehospital. Metamizole was used 8.59 (12.51) times, ketamine 3.51 (5.23) times, opioids 10.72 (16.18) times and naloxone 0.20 (0.67) times prehospital. Glucose was administered 7.38 (6.67) times prehospital.Conclusion: It is difficult to evaluate which drugs are suitable for administration by paramedics because of lacking evidence or consensus about an indicated number of administrations. Therefore, an evaluation can only be derived from clinical experience. However from the authors’ point of view the paramedics have satisfactory expertise for administering most of the investigated drugs.