The use of petrochemical solvents still occupies the major portion in many chemical procedures despite their negative effects against environment and human health. Thus, green and sustainable solvents have been investigated as their substitutes. In this study, R-(-)-carvone was examined as a potential candidate for novel bio-based solvent and was mixed with various classes of natural compounds including carboxylic acids, terpenes and benzoate ester. The resulting mixtures were hydrophobic, and their solid-liquid equilibrium phase diagrams unveiled a wide liquid window for many mixtures. Computational and empirical investigation revealed that the carvone-based mixtures could have varying properties in terms of density and polarity, while they generally had low viscosity and reasonable biodegradability. These mixtures was applied to liquid-liquid partition of two hydrophilic and hydrophobic model dyes. They also showed different performances in the extraction of natural hydrophobic pigments from red algae (laver). The current study suggests the carvone-based mixtures as novel versatile green solvents that can be tuned to possess diverse properties.