This study aimed to identify the factors affecting the vulnerability and resilience of Seoul"s neighborhoods by analyzing the recent commercial resilience of social changes such as online shopping. Commercial resilience was defined as "the ability to absorb the impact of online shopping and adapt to change", and the demographic and commercial characteristics that affect the use of online shopping were analyzed. Thereafter, the factors affecting commercial resilience have been integrally analyzed. According to this study, regional differences exist in online shopping practices, and regional population, social characteristics, and physical and commercial characteristics have a combined effect. In addition, the analysis showed that the retail ratio of neighboring commercial districts negatively affects commercial resilience. Finally, it was confirmed that population density, land use diversity, and income, which are closely related to the revitalization of the commercial district, have no influence on the resilience to the impact of online shopping, or rather have the opposite result. Today"s online shopping causes a great crisis for the neighborhood, and the neighborhood needs to be fundamentally reinvented to survive. According to the results of this study, the conversion of neighborhood centers into food and service industries is irreplaceable for online shopping. Neighborhood centers provide leisure, social cohesion, and resilience to the local community. The future of these neighborhoods depends on appropriate urban planning and urban design issues.