The present disclosure provides a mobile phone protective sleeve with a novel waterproof structure. The mobile phone protective sleeve with the novel waterproof structure comprises a lower cover, an upper cover and a screen protection sheet hermetically connected to the upper cover, wherein the lower cover comprises a base plate and a lower cover mounting sleeve, a sealing groove is formed in the inner wall of the lower cover mounting sleeve circumferentially, the base plate is arranged at the middle part of the lower cover mounting sleeve, and the upper cover comprises an internal part hard rubber frame, an external part hard rubber frame and a soft rubber frame arranged on the outer side of the external part hard rubber frame. The waterproof stability can be effectively guaranteed through the external part hard rubber frame and the internal part hard rubber frame.