A refrigeration door system with a defrosting feature includes a housing defining a refrigerated cavity therein, and a door assembly carried by the housing and providing access to the refrigerated cavity. The door assembly includes a door frame and a sliding door coupled to the door frame, the sliding door switching between an open position providing the access to the refrigerated cavity and a closed position where the refrigerated cavity is inaccessible. The door frame includes a top member having a first end and a second end opposite the first end, a first side member coupled transversely to the first end of the top member and having a side conduit therein, a second side member coupled transversely to the second end of the top member, and a medial member coupled transversely to the top member between the first end and the second end of the top member.