An LED lamp with an LED lamp light guide of ultra-high brightness and large angle, including a lamp holder, a lampshade, an LED light source, and the light guide is provided. The lamp holder is fastened with the lampshade, the LED light source is arranged in the lamp holder and connected to a power source through the lamp holder, the light guide is arranged inside the lamp holder and the lampshade, and the light guide is a long bar with four wing plates perpendicularly connected to each other in a cross shape when viewed longitudinally.