Provided are an anti-microbial matrix and filtration systems containing the same. The matrix comprises a surface-modified inorganic component and a polymeric binder comprising particles having an irregular, convoluted surface. The surface-modified inorganic component comprises a reaction product of an anti-microbial component and an inorganic component. The anti-microbial component comprises a quaternary ammonium salt containing an epoxide group. A covalent bond is, for example, between the quaternary ammonium cation and a hydroxyl group of the inorganic component. The quaternary ammonium salt can be poly(methyldiallylamine epichlorohydrin). Further, the quaternary ammonium salt can have the formula according to I: (Formula I), wherein n is in the range of 5 to 24. The inorganic component can be diatomaceous earth. The polymeric binder can comprise ultra high molecular weight polyethylene (UHMW PE). Methods of making and using the same are also provided.