Solid-in-oil dispersion: A novel core technology for drug delivery systems
- Resource Type
- Academic Journal
- Authors
- Tahara, Yoshiro; Kamiya, Noriho; Goto, Masahiro
- Source
- International Journal of Pharmaceutics. Nov 01, 2012 438(1):249-257
- Subject
- Language
- English
- ISSN
- 0378-5173
Drug delivery systems using a solid-in-oil (S/O) dispersion as a core technology have advanced significantly over the past ten years. A novel, effective and practical preparation method for a S/O dispersion was originally established in 1997 as a tool for enzymatic catalysis in organic media. This oil-based dispersion containing proteins in non-aqueous media had great potential for applications to other research with one of the most successful being its adaptation as a drug delivery system. The history and features of novel processes for preparing S/O dispersions are presented in this article. In addition, recent research into the use of S/O dispersions for innovative oral and skin drug delivery systems is discussed.