INTRODUCTION:: There is limited information in regards to complication rates of this procedure in singleton pregnancies, which makes it difficult to counsel patients. Our goal is to evaluate indications, pregnancy outcomes and risk of adverse events following isolated amnioreduction procedures in singleton gestations. METHODS:: Retrospective cohort of all amnioreduction procedures performed on singleton gestations complicated by polyhydramnios between January 2011 and June 2018 at our referral center. Clinical indications for amnioreduction procedures were categorized as either maternal shortness of breath, maternal sense of abdominal tightness, or preterm uterine contractions. Outcome variables included preterm premature rupture of membranes (PPROM), placental abruption, chorioamnionitis and preterm delivery in isolation or in composite. Data were tested for normality and reported as mean±SD, median [range] and n (%). RESULTS:: 33 patients underwent a median number of 1 [range 1-12] amnioreductions, yielding a total of 66 amnioreduction procedures. Estimated gestational age at delivery in this subgroup was 36 [30-40]. Among the study cohort, there were no instances of PPROM, placental abruption, chorioamnionitis or preterm delivery 12 hrs following the procedure. However, 7/66 (10.6%) of amnioreductions resulted in preterm delivery 12-48 hr post procedure. There were 2 cases of active preterm labor, 2 cases of non-reassuring fetal heart tracing, 1 case of preeclampsia with severe features, and 2 cases with mirror syndrome. CONCLUSION:: Our data suggests that among singleton gestations, approximately 10% will experience a preterm birth, but none in the immediate procedure interval. This data may be used in counseling of potential candidates of amnioreduction with singleton pregnancies.