ABSTRACT: Dual epidemics of coronavirus disease 2019 (COVID-19) and HIV cause burnout among HIV health care workers. Guided by a socioecological framework, we investigated risk and protective factors of their burnout in Guangxi, China based on an online survey (N = 1,029) from April to May 2020. Descriptive and bivariate analyses and hierarchical regression were conducted. COVID-19–related stressors (B = 0.648 [0.482–0.816], p < .001), challenges while delivering HIV services (B = 0.236 [0.174–0.298], p < .001), and working in province/city-level institutes (B = 2.302, [0.828–3.776], p =.002) were risk factors. Protective factors were resilience (B = −0.596 [−0.687 to −0.504], p < .001), workplace social support (B = −0.410 [−0.717 to −0.044], p =.03), and institutional responsiveness to COVID-19 (B = −0.138 [−0.205 to −0.071], p < .001), respectively. Burnout-related interventions may benefit from promoting resilience, creating a supportive work environment, and strengthening institutional response to public health emergencies.