BACKGROUND:: Finite element analysis, characterized by repeatable and comprehensive performance test, has been frequently utilized in biomechanics analysis of fracture and fixation, such as forearm fracture, but there are few studies on distal radioulnar joints. OBJECTIVE:: To establish and validate a more precise three-dimensional (3D) finite element model (FEM) of distal radioulnar joint. METHODS:: Data of CT and MRI sectional images, obtained from a healthy man, were inputed into MIMICS10.1 and ANSYS10.0 to generate 3D finite element model of distal radioulnar joint. Simulating under bending load, axial compression load and the torsion load conditions, the Vonmises stress distribution of distal radioulnar joint were detected and compared with the results of experiment in vitro for validation. RESULTS AND CONCLUSION:: The model consisted of 333 805 elements and 508 384 nodes, which reflected the real geometric structure of the distal radioulnar joint objectively. Under bending, axial compression and the torsion load conditions, theoretical analysis results are consistent well in biomechanics. The current finite element model of the distal radioulnar joint can properly simulate the characteristic of the distal radioulnar joint in biomechanics testing.