POLYCYSTIC KIDNEY DISEASE: Polycystin-1 and polycystin-2—itʼs complicated
- Resource Type
- Academic Journal
- Authors
- Watnick, Terry J.; Germino, Gregory G.
- Source
- Nature Reviews Nephrology. May 01, 2013 9(5):249-250
- Subject
- Language
- English
- ISSN
- 1759-5061
Mutations in the genes that encode polycystin-1 and polycystin-2 are the principal cause of autosomal dominant polycystic kidney disease. These proteins form a receptor-ion-channel complex and were thought to regulate tubule luminal diameter in a codependent manner. However, new data suggest a more antagonistic relationship between the proteins.