Gender Differences in Drug Bioequivalence: Time to Rethink Practices
- Resource Type
- Academic Journal
- Authors
- Koren, G; Nordeng, H; MacLeod, S
- Source
- Clinical Pharmacology & Therapeutics. Mar 01, 2013 93(3):260-262
- Subject
- Language
- English
- ISSN
- 0009-9236
Currently, bioequivalence (BE) studies are carried out exclusively in males, assuming that intrasubject variabilities are similar between the sexes. This article challenges this hypothesis on the basis of available evidence and urges that studies of BE of sufficient power be undertaken in women also for all generic drugs aimed at women.