Abstract 15227: Decreased Left Atrial Emptying Fraction is Associated With Increased Odds of Diagnosing Atrial Fibrillation Within 1 Year of ESUS
- Resource Type
- Academic Journal
- Authors
- Shah, Ravi S; Raco, Joseph; Williams, Ryan; McConkey, Nathaniel; Foley, David; Mills, Kevin; Hegwood, Emma; Jia, Kelly; Maheshwari, Ankit
- Source
- Circulation. Nov 08, 2022 146(Suppl_1 Suppl 1):A15227-A15227
- Subject
- Language
- English
- ISSN
- 0009-7322
Introduction: A significant proportion of patients with embolic stroke of unknown source (ESUS) are subsequently diagnosed with atrial fibrillation (AF). Left atrial myopathy characterized by mechanical left atrial dysfunction has been associated with development of AF.Hypothesis: Decreased left atrial emptying fraction (LAEF) is independently associated with AF in patients with ESUS.Methods: Patients admitted at a tertiary care medical center for ESUS treated with implantable loop recorders from 2015-2022 were included. Patients were excluded for lack of an interpretable transthoracic echocardiogram during sinus rhythm and electrocardiogram with 6 months of ESUS. Patients were also excluded for lack of clinical follow-up. Co-variates (table) were ascertained from chart review. LAEF was calculated by Simpson’s method of discs.Results: 153 patients were included. The mean(standard deviation) LAEF of patients who developed and did not develop AF within 1 year post ESUS was 48.0%(17.0%) and 57.6%(13.1%), respectively (P<0.001). The odds of diagnosing atrial fibrillation within 1 year post ESUS were 7.18-fold greater in patients with LAEF<40%.Conclusions: LAEF is independently associated with increased odds of AF within 1 year post ESUS. Future research is needed to validate these findings.