GRN 3′UTR+78 C>T is not associated with risk for Parkinsonʼs disease
- Resource Type
- Academic Journal
- Authors
- Jasinska-Myga, B.; Wider, C.; Opala, G.; Krygowska-Wajs, A.; Barcikowska, M.; Czyzewski, K.; Baker, M.; Rademakers, R.; Uitti, R. J.; Farrer, M. J.; Ross, O. A.; Wszolek, Z. K.
- Source
- European Journal of Neurology. Aug 01, 2009 16(8):909-911
- Subject
- Language
- English
- ISSN
- 1351-5101
BACKGROUND AND PURPOSE:: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. METHODS:: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinsonʼs disease in two Caucasian patient-control series (n = 1413) from the US and Poland. RESULTS:: No association was observed between rs5848 and susceptibility to Parkinsonʼs disease (individual series and combined analysis). CONCLUSIONS:: This finding shows that GRN rs5848 does not affect the risk of Parkinsonʼs disease in the US and Polish populations.