Does calcium cause the different effects of Gelofusine and Haemaccel on coagulation?
- Resource Type
- Academic Journal
- Authors
- Coats, T J; Heron, M
- Source
- EMERGENCY MEDICINE JOURNAL. Mar 01, 2006 23(3):193-194
- Subject
- Language
- English
- ISSN
- 1351-0622
BACKGROUND:: Gelofusine (which does not contain calcium) has a greater effect on coagulation than Haemaccel (which contains 6.25 mmol/l of calcium). This in vitro study was performed to assess whether calcium might be the cause of the different effects on coagulation. METHODS:: Three solutions were compared; (a) Gelofusine, (b) Gelofusine with calcium added to 6.25 mmol/l, and (c) Haemaccel. Thromboelastography (Sonoclot) was used to examine whole blood coagulation, with time to peak clot weight as the primary outcome measure. RESULTS:: There was no significant difference between the Gelofusine containing solutions. Both Gelofusine solutions gave a greater impairment of coagulation than the Haemaccel solution. CONCLUSIONS:: The different effect of Gelofusine on coagulation compared with Haemaccel does not seem to be related to the different calcium contents of the solutions.