BACKGROUND:: Despite safe and cost-effective venous thromboembolism (VTE) prevention measures, VTE prophylaxis rates are often suboptimal. Healthcare reform efforts emphasize transparency through programs to report performance and payment incentives through pay-for-performance programs. OBJECTIVE:: To sequentially examine an individualized physician dashboard and pay-for-performance program to improve VTE prophylaxis rates among hospitalists. DESIGN:: Retrospective analysis of 3144 inpatient admissions. After a baseline observation period, VTE prophylaxis compliance was compared during both interventions. SETTING:: A 1060-bed tertiary care medical center. PARTICIPANTS:: Thirty-eight part-time and full-time academic hospitalists. INTERVENTIONS:: A Web-based hospitalist dashboard provided VTE prophylaxis feedback. After 6 months of feedback only, a pay-for-performance program was incorporated, with graduated payouts for compliance rates of 80% to 100%. MEASUREMENTS:: Prescription of American College of Chest Physiciansʼ guideline-compliant VTE prophylaxis and subsequent pay-for-performance payments. RESULTS:: Monthly VTE prophylaxis compliance rates were 86% (95% confidence interval [CI]: 85–88), 90% (95% CI: 88–93), and 94% (95% CI: 93–96) during the baseline, dashboard, and combined dashboard/pay-for-performance periods, respectively. Compliance significantly improved with the use of the dashboard (P = 0.01) and addition of the pay-for-performance program (P = 0.01). The highest rate of improvement occurred with the dashboard (1.58%/month; P = 0.01). Annual individual physician performance payments ranged from $53 to $1244 (mean $633; standard deviation ±$350). CONCLUSIONS:: Direct feedback using dashboards was associated with significantly improved compliance, with further improvement after incorporating an individual physician pay-for-performance program. Real-time dashboards and physician-level incentives may assist hospitals in achieving higher safety and quality benchmarks. Journal of Hospital Medicine 2015;10:172–178. © 2014 Society of Hospital Medicine