Uveitis is uncommon in patients with multiple sclerosis (MS), but the link between the two entities is clearly established. While a common etiology or pathologic process remains unknown, shared human leukocyte antigens suggest a genetic predisposition. The treatment for MS-associated uveitis is not distinct from treatment of other types of noninfectious uveitis, but interferons may serve as a common therapeutic avenue for both CNS and eye disease. Further study is needed to better understand MS-associated uveitis and its link to demyelinating CNS disease.