SIGNIFICANCE: When exploring relationships among clinical measures and patient-reported outcome measures in adults with convergence insufficiency, worse symptoms (Convergence Insufficiency Symptom Survey score) appeared to be correlated with worse Reading Function domain score (Adult Strabismus-20 quality-of-life questionnaire). After treatment, improved symptoms were associated with improved reading function quality of life. PURPOSE: To explore relationships between clinical measures and patient-reported outcome measures in adults undergoing treatment for symptomatic convergence insufficiency. METHODS: In a prospective multicenter observational study we evaluated adults with symptomatic convergence insufficiency (i.e., clinical measures of near exodeviation, receded near point of convergence, reduced near positive fusional vergence; Convergence Insufficiency Symptom Survey (CISS) score ≥ 21). Fifty-seven participants treated with vision therapy/exercises (n = 35) or base-in prism (n = 22) were analyzed. Spearman correlation coefficients (R) were used to assess associations among the 3 clinical measures and patient-reported outcome measures (CISS, Diplopia Questionnaire, four Adult Strabismus-20 quality-of-life domains) before treatment (baseline) and after 10 weeks and 1 year. Associations were interpreted to be present when the lower limit of the 95% confidence interval (CI) was moderate-to-strong [R ≥ 0.4]. RESULTS: Among multiple exploratory analyses, the only moderate-to-strong baseline correlation was between worse CISS and worse Adult Strabismus-20 Reading Function scores (R = 0.62, 95% CI: 0.43 to 0.76). Regarding change in measures with treatment, the only moderate-to-strong correlations were between improved CISS and improved AS-20 Reading Function scores for prism at 10 weeks (R = 0.78, 95% CI: 0.52 to 0.91) and 1 year (R = 0.85; (95% CI: 0.65 to 0.94), and for vision therapy/exercises at 1 year (R = 0.78, 95% CI: 0.57 to 0.89). CONCLUSIONS: In exploratory analyses, we found positive correlations between CISS symptom scores and reading function quality-of-life scores. The absence of correlations between symptoms and individual clinical measures is consistent with clinical experience, that in convergence insufficiency, symptoms and clinical findings can be discordant.