Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia
- Resource Type
- Academic Journal
- Authors
- Ratner, Lee; Grant, Christian; Zimmerman, Bevin; Fritz, Joseph; Weil, Gary; Denes, Alex; Suresh, Rama; Campbell, Nancy; Jacobson, Steve; Lairmore, Michael
- Source
- American Journal Of Hematology. Oct 01, 2007 82(10):929-931
- Subject
- Language
- English
- ISSN
- 0361-8609
Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patientʼs viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation.