ABSTRACT: F–prostate-specific membrane antigen (PSMA) 1007 is one of the most promising radiotracers for PET imaging in prostate cancer, minimal urinary clearance, and higher spatial resolution, which are the most outstanding features. PSMA can also be labeled with Cu, offering a longer half-life and different resolution imaging. We present images of metastatic prostate cancer in two patients, where Cu-PSMA PET/CT was performed one day after F-PSMA-1007 PET/CT. In the two patients, both radiotracers provided high image quality and a similar range of detection for metastatic lesions.