N-Acetyl-L-Cystein downregulates β-amyloid precursor protein gene transcription in human neuroblastoma cells
- Resource Type
- Academic Journal
- Authors
- Studer, Rolf; Baysang, Ginette; Brack, Christine
- Source
- Biogerontology. Jan 01, 2001 2(1):55-60
- Subject
- Language
- English
- ISSN
- 1389-5729
The causes for the sporadic form of Alzheimerʼs disease (AD) are still poorly understood, except from the fact that age is an important risk factor. The main component of the characteristic amyloid plaques in brains of AD patients are Aβ peptides, derivatives of the amyloid precursor protein APP. Oxidative stress may contribute to the aetiology of AD by dysregulation of APP metabolism. Overexpression of the APP gene could result in an increased secretion of neurotoxic Aβ peptides, while preventing the overexpression might be protective. We here report that the antioxidant N-Acetyl-L-Cystein (NAC) downregulates APP gene transcription in human neuroblastoma cells. The effect is reversible when cells are returned to NAC free medium. These results open up new possibilities for the development of therapeutic agents that intervene at the transcriptional level.