Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians
- Resource Type
- Academic Journal
- Authors
- Tsegaye, Aster; Ran, Leonie; Wolday, Dawit; Petros, Beyene; Nanlohy, Nening M; Meles, Hailu; Girma, Mulu; Hailu, Ermias; Borghans, José; Miedema, Frank; Baarle, Debbie van
- Source
- AIDS. Jan 30, 2007 21(3):369-372
- Subject
- Language
- English
- ISSN
- 0269-9370
We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/μl per year) and five with a fast (> 45 cells/μl per year) CD4 T-cell decline longitudinally. Six study subjects had T-cell responses directed to one or more HIV-1 Gag peptides. The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype.