BACKGROUND: HIV preexposure prophylaxis (PrEP) remains underutilized despite its efficacy and potential population impact. Achieving PrEP’s full potential depends upon providers who are knowledgeable and comfortable prescribing it to individuals at risk of acquiring HIV. Previous educational interventions targeting provider-related uptake barriers have had limited success. We designed and tested an electronic medical record (EMR) interpretative comment to improve the delivery of PrEP. METHODS: An EMR comment provided information on PrEP eligibility and referral resources to providers delivering positive chlamydia and gonorrhea results. Positive tests for bacterial sexually transmitted infections pre-intervention (01/01/19 - 08/23/19) and post-intervention (08/24/19 - 12/31/19) were identified. A retrospective chart review was conducted to ascertain provider documentation of PrEP discussions or provision, HIV prevention discussions, and HIV screening. Pretest-posttest analysis was performed to compare the provision of PrEP and HIV prevention services. RESULTS: We reviewed 856 pre-intervention encounters spanning eight months and 461 post-encounters spanning four months. Patient demographics were comparable. We observed an increase in provider documentation of safe sex and condom counseling (respectively, OR 1.2, 95% CI 1.07-1.18: OR 1.11, 95% CI 1.05-1.17), and the absence of any HIV prevention discussion decreased (OR 0.85, 95% CI 0.80-0.90), but not HIV screening or PrEP documentation. CONCLUSIONS: We demonstrated that an EMR lab comment had a modest effect on increasing risk reduction counseling, though not HIV screening or PrEP prescriptions. Future strategies to encourage provider delivery of sexual health services may benefit from more targeted strategies that combine behavioral and IT approaches.