This study was conducted to identify job stress, nursing work environment, and turnover intention for nurses at COVID-19 dedicated hospital, and to identify factors influencing turnover intention. From September 1 to September 27, 2022, 144 nurses at a COVID-19 dedicated hospital in the I area were collected. The collected data used the SPSS Statistics 23.0 program. As a result of the study, the intention to turnover according to general characteristics showed significant differences in work experience (F=11.20, p<.001), and by position (F=4.09, p=.009). In addition, turnover intention showed a significant correlation with job stress (r=.561, p<.001) and nursing work environment (r=-.382, p<.001). The factors influencing turnover intention were job stress (β=.46, p<.001), work experience of more than 11 years (β=.34, p<.001), work experience of 3-10 years (β=.20, p=.022), nursing work environment (β=-.22, p=.001), and 43.9% of explanatory power. Accordingly, in order to reduce the intention to turnover of nurses at hospitals dedicated to COVID-19, it is necessary to create measures to reduce job stress and an efficient nursing work environment considering the characteristics of work by career in infectious disease situations.