This study examined whether anger-expression mode moderated the association between rejection sensitivity and interpersonal problems. The participants were 335 university students who were asked to complete the Rejection Sensitivity Questionnaire(RSQ), State-Trait Anger Expression Inventory-Korean version(STAXI-K), and the Short form of the Korean Inventory of Interpersonal Problems Circumplex Scale(KIIP-SC). The results of Process Macro analysis indicated that anger-expression mode moderated the impact of rejection sensitivity on interpersonal problems. Specifically, anger-out and anger-in moderated the relationship between rejection sensitivity and isolation type interpersonal problems. In addition, anger-out moderated the relationship between rejection sensitivity and aggression type interpersonal problems. However, anger-expression mode had no moderating effect on the relationship between rejection sensitivity and obedience type interpersonal problems. Additionally, anger-control had no moderating effect on the relationship between rejection sensitivity and the three types of interpersonal problems. Based on these results, the implications and limitations of the present study, and directions for future research are discussed.